Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-β

MR microscopy of human amyloid-β deposits: characterization of parenchymal amyloid, diffuse plaques, and vascular amyloid.

Cerebral deposits of amyloid-β peptides (Aβ) form the neuropathological hallmarks of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In the brain, Aβ can aggregate as insoluble fibrils present in amyloid plaques and vascular amyloid, or as diffuse plaques consisting of mainly non-fibrillar Aβ. Previously, magnetic resonance imaging (MRI) has been shown to be capable of detecting...

Metal Chelator Decreases Alzheimer β-Amyloid Plaques

five CQ-treated mice, and two showed no measurable Alzheimer ␤-Amyloid Plaques A␤ in the pellet fraction and no detectable A␤ pathology by immunocytochemistry. The authors then examined the effects of a higher dose (30 mg/kg/d) for 9 weeks in older 21-month-old mice (n ϭ 20) as compared to Transgenic mice developing ␤-amyloid (A␤) plaques sham-fed mice (n ϭ 19). This resulted in a 41% decrease ...

SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques

The development of radiotracers for use in vivo to image β-amyloid (Aβ) plaques in cases of Alzheimer's disease (AD) is an important, active area of research. The presence of Aβ aggregates in the brain is generally accepted as a hallmark of AD. Since the only definitive diagnosis of AD is by postmortem staining of affected brain tissue, the development of techniques which enable one to image Aβ...

Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-β plaques in a mouse model of amyloid-β deposition.

Dendritic spines are the site of most excitatory synapses, the loss of which correlates with cognitive impairment in patients with Alzheimer disease. Substantial evidence indicates that amyloid-β (Aβ) peptide, either insoluble fibrillar Aβ deposited into plaques or soluble nonfibrillar Aβ species, can cause spine loss but the concurrent contributions of fibrillar Aβ and nonfibrillar Aβ to spine...

Amyloid Plaques and Amyloid- Oligomers: An Ongoing Debate